When do I pick a 12 over a 5 seed? Part 1

Whenever a 12 seed is from a major conference and the 5 seed is from a mid-major, take the 12 seed.

The 12 seed is undefeated in this scenario going back to the last major conference re-alignment in 1991.

We are currently looking at other rules.  One that has our attention is when a major plays against another major and the one major plays in the finals of their conference tournament (Florida State last year, Syracuse the year they lost to Texas A&M in Gerry McNamara's senior year).

We'll let you know what we find.